Debido a la gran afinidad de las regiones homólogas de los cromosomas para aparear durante la meiosis, los diploides que disponen de una dotación cromosómica normal y otra que incluye alguna reorganización cromosómica generan estructuras cromosómicas emparejadas con formas y propiedades características de la reorganización.
Una deleción en una dotación cromosómica resulta generalmente deletérea, debido a que se producen desequilibrios génicos y a la manifestación de los alelos nocivos presentes en la otra dotación cromosómica.
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Un número par de dotaciones cromosómicas poliploides es más probable que resulte fértil. En esta condición, las proporciones de segregación para cada locus individual difieren de las de los diploides.
El cruzamiento entre dos especies diferentes y la duplicación subsiguiente del número de cromosomas en el híbrido producen una clase especial de poliploide fértil interespecífico.
Generalmente, las variantes que han ganado o perdido un cromosoma se originan por falta de disyunción (segregación cromosómica anormal en meiosis o mitosis).
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Cuando son fértiles, estas variantes presentan proporciones anormales de segregación génica únicamente para el cromosoma implicado.
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